Determining the OPTIMAL DTI analysis method for application in cerebral small vessel disease.

ABSTRACT:

Background

DTI is sensitive to white matter (WM) microstructural damage and has been suggested as a surrogate marker for phase 2 clinical trials in cerebral small vessel disease (SVD). The study's objective is to establish the best way to analyse the diffusion-weighted imaging data in SVD for this purpose. The ideal method would be sensitive to change and predict dementia conversion, but also straightforward to implement and ideally automated. As part of the OPTIMAL collaboration, we evaluated five different DTI analysis strategies across six different cohorts with differing SVD severity.

Methods

Those 5 strategies were: (1) conventional mean diffusivity WM histogram measure (MD median), (2) a principal component-derived measure based on conventional WM histogram measures (P

SUBMITTER: Egle M 

PROVIDER: S-EPMC9421487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature