Involvement of cerebellar and subcortical connector hubs in schizophrenia.

ABSTRACT:

Background

Schizophrenia is considered a brain connectivity disorder in which functional integration within the brain fails. Central to the brain's integrative function are connector hubs, brain regions characterized by strong connections with multiple networks. Given their critical role in functional integration, we hypothesized that connector hubs, including those located in the cerebellum and subcortical regions, are severely impaired in patients with schizophrenia.

Methods

We identified brain voxels with significant connectivity alterations in patients with schizophrenia (n = 76; men = 43) compared to healthy controls (n = 80; men = 43) across multiple large-scale resting state networks (RSNs) using a network metric called functional connectivity overlap ratio (FCOR). Fr

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC9421528 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature