Voxelwise structural disconnection mapping: Methodological validation and recommendations.

ABSTRACT: Voxelwise disconnection mapping is a novel approach to disclose lesion-symptom relationships for symptoms caused by white matter disconnection. It uses MRI-based fiber tracking in healthy subjects seeded from patient's focal brain lesions. Resulting individual disconnection maps can then be statistically associated with symptoms. Despite increasing use in the recent years, the validity of this approach remains to be investigated. In this study, we validated both, our own implementation and the implementation provided within BCBtoolkit. For technical validation, we used simulated symptoms based on overlap of 70 real stroke lesions with tracts from a white matter atlas. For clinical validation, paresis scores and lesions from 316 patients with stroke were used. We found that voxelwise discon

SUBMITTER: Wawrzyniak M 

PROVIDER: S-EPMC9421530 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature