Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis.

ABSTRACT:

Background & aims

Parenteral nutrition (PN) is a lifesaving therapy for patients with intestinal failure. Hepatic steatosis is a potentially fatal complication of long-term PN, but the involved pathological mechanisms are incompletely unclarified. Herein, we identify the role of protein phosphatase 2A (PP2A) in the pathogenesis of parenteral nutrition-associated hepatic steatosis (PNAHS).

Methods

Proteomic/phosphoproteomic analyses of liver samples from patients with PNAHS were applied to identify the mechanism of PNAHS. Total parenteral nutrition (TPN) mice model, in vivo, and in vitro experiments were used to assess the effect of PP2A-Cα on liver fatty acid metabolism.

Results

Reduced expression of PP2A-Cα (catalytic subunit) enhanced activation of serine/threonine

SUBMITTER: Maitiabula G 

PROVIDER: S-EPMC9421584 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature