β-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease.

ABSTRACT:

Background

Abnormal metabolism of amyloid-β (Aβ) and soluble P-tau, as well as neurodegeneration, are key components of Alzheimer's disease (AD), but it is unclear how these different processes are related to genetic risk factors for AD.

Method

In the Swedish BioFINDER study, we tested associations between a priori defined polygenic risk scores (PRSs) for AD (excluding Single Nucleotide Polymorphism [SNPs] within the apolipoprotein E [APOE] region in the main analysis) and biomarkers in cerebrospinal fluid (CSF) (Total tau [T-tau] and Phosphorylated tau181 [P-tau181], Aβ1-38, Aβ1-40, Aβ1-42 and Aβ1-42/1-40, neurofilament light [NfL]) in Cognitively Unimpaired (CU) individuals (n=751), and in Mild Cognitive Impairment (MCI) (n=212), and AD dementia (n=150) patients. Re

SUBMITTER: Kumar A 

PROVIDER: S-EPMC9421595 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature