A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men.

ABSTRACT:

Introduction

Although previous genome-wide association studies (GWASs) have identified genetic susceptibility loci for abdominal adiposity, GWASs on Asian samples remain scarce. Therefore, we performed a GWAS for abdominal adipose tissue depots in a Korean population.

Methods

A total of 1,937 Korean men were included in the study. Areas of abdominal fat were quantified by computed tomography. We performed a GWAS analysis under an additive model, and a replication study was conducted on 480 additional Korean adult men.

Results

In the discovery step, we identified a total of 10 single-nucleotide polymorphisms (SNPs) associated with adiposity indicators (p < 1 × 10-5). The top SNP, rs1028014, for visceral adipose tissue (VAT) was located in the ZMAT4 gene and remained si

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC9421669 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature