Machine Perfusion in Liver Transplantation: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Liver transplantation (LTx) is the only treatment option for patients with end-stage liver disease. Novel organ preservation techniques such as hypothermic machine perfusion (HMP) or normothermic machine perfusion (NMP) are under investigation in order to improve organ quality from extended criteria donors and donors after circulatory death. The aim of this study was to systematically review the literature reporting LTx outcomes using NMP or HMP compared to static cold storage (SCS).

Methods

The following data were retrieved: graft primary nonfunction rate, early allograft dysfunction (EAD) rate, biliary complication rate, and 12-month graft and patient survival. A total of 15 studies were included (6 NMP and 9 HMP studies), and meta-analysis was performed only fo

SUBMITTER: Jakubauskas M 

PROVIDER: S-EPMC9421699 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature