¹H Hyperpolarization of Solutions by Overhauser Dynamic Nuclear Polarization with ¹³C-¹H Polarization Transfer.

ABSTRACT: Dynamic nuclear polarization (DNP) is a method that can significantly increase the sensitivity of nuclear magnetic resonance. The only effective DNP mechanism for in situ hyperpolarization in solution is Overhauser DNP, which is inefficient for ¹H at high magnetic fields. Here we demonstrate the possibility of generating significant ¹H hyperpolarization in solution at room temperature. To counter the poor direct ¹H Overhauser DNP, we implement steady-state ¹³C Overhauser DNP in solutions and then transfer the ¹³C hyperpolarization to ¹H via a reverse insensitive nuclei enhanced by polarization transfer scheme. We demonstrate this approach using a 400 MHz gyrotron-equipped 3.2 mm magic angle spinning DNP system to obta

SUBMITTER: Rao Y 

PROVIDER: S-EPMC9421900 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature