Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression.

ABSTRACT:

Background

Long non-coding RNA (lncRNA) is an endogenous RNA over 200 nt in length involved in gene regulation. LINC01559 is a novel lncRNA that has been identified as a fundamental player in human cancer. However, its role in triple-negative breast cancer (TNBC) remains unknown. Here, we explored the expression, function and clinical implication of LINC01559 in TNBC.

Methods

RNA expression was detected by qRT-PCR analysis. Cell Counting Kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU), wound healing and Transwell assays were used to test cell viability, DNA synthesis rate, migration and invasion, respectively. The competing endogenous RNA (ceRNA) axis involved in LINC01559 was determined by RNA pull-down and luciferase reporter assays. The xenograft model was used to verify t

SUBMITTER: Yang X 

PROVIDER: S-EPMC9421927 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature