M7G-Associated subtypes, tumor microenvironment, and validation of prognostic signature in lung adenocarcinoma.

ABSTRACT: Background: 7-Methylguanosine (m7G) is an important posttranscriptional modification that regulates gene expression and is involved in tumorigenesis and development. Tumor microenvironment has been proven to be highly involved in tumor progression and prognosis. However, how m7G-associated genes affect the tumor microenvironment of patients with lung adenocarcinoma (LUAD) remains to be further clarified. Methods: The genetic alterations of m7G-associated genes and their associations with the prognosis and tumor microenvironment in LUAD patients were systemically analyzed. An m7G-Riskscore was established and analyzed for its performance in disease prognosis and association with patient response to immunotherapy. Expression of the model genes at the protein level was investiga

SUBMITTER: Wang G 

PROVIDER: S-EPMC9422053 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature