Cellular transcriptional alterations of peripheral blood in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common cause of dementia worldwide. Accumulating data support the contributions of the peripheral immune system in AD pathogenesis. However, there is a lack of comprehensive understanding about the molecular characteristics of peripheral immune cells in AD.

Methods

To explore the alterations of cellular composition and the alterations of intrinsic expression of individual cell types in peripheral blood, we performed cellular deconvolution in a large-scale bulk blood expression cohort and identified cell-intrinsic differentially expressed genes in individual cell types with adjusting for cellular proportion.

Results

We detected a significant increase and decrease in the proportion

SUBMITTER: Song L 

PROVIDER: S-EPMC9422129 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature