Posttranslational control of lipogenesis in the tumor microenvironment.

ABSTRACT: Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9422141 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature