Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study.

ABSTRACT:

Background

The incidence of pulmonary embolism complications in the literature ranges from 10 to 50%, with a 0.5-10% risk of fatal pulmonary embolism. However, the biological cause of pulmonary embolism is unknown.

Methods

This study used data from the Genome-Wide Association Study (GWAS) of Pulmonary Embolism and Human Blood Metabolites from the UK Biobank, and the data from subjects of European ancestry were analyzed. We explored the relationship between pulmonary embolism and blood metabolites in three ways. We first analyzed the genetic correlation between pulmonary embolism and human blood metabolites using the linkage disequilibrium score regression (LDSC) and then analyzed the causal relationship between pulmonary embolism and meaningful blood metabolites obtained fro

SUBMITTER: Feng R 

PROVIDER: S-EPMC9422150 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature