Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study.

ABSTRACT:

Background

Abnormal activation of immune system is an important pathogenesis of Parkinson's disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remains unclear.

Objectives

To evaluate the brain regional microglia activation and its relationship with clinical severity, dopaminergic presynaptic function, and peripheral inflammatory biomarkers related to adaptive immunity.

Methods

In this case-control study, we recruited 23 healthy participants and 24 participants with early-stage Parkinson's disease. ¹⁸F-PBR06 PET/MR for microglia activation, ¹⁸F-FP-DTBZ for dopaminergic denervation, total account of T cells and subpopulations of T helper (Th1/Th2/Th17) cells, and the levels of s

SUBMITTER: Liu SY 

PROVIDER: S-EPMC9422161 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature