Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling.

ABSTRACT:

Background

Recently, a few studies have indicated a relationship between the gut microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the pathogenesis of IgAN and whether probiotics are effective in treating IgAN are still controversial. Therefore, this study aimed to identify the differences in the structure of the gut microbiota between IgAN and controls and to evaluate the efficacy and mechanism of probiotics in the treatment of IgAN.

Methods

To address this question, 35 IgAN patients and 25 healthy volunteers were enrolled, and a mouse IgAN model was also constructed. The stool microbes were analyzed by 16S rRNA high-throughput sequencing to identify the differential strains between IgAN and healthy controls. The impact of probiotics on the s

SUBMITTER: Tan J 

PROVIDER: S-EPMC9422169 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature