Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies.

ABSTRACT: Natural killer (NK) cells belong to the family of innate immune cells with the capacity to recognize and kill tumor cells. Different phenotypes and functional properties of NK cells have been described in tumor patients, which could be shaped by the tumor microenvironment. The discovery of HLA class I-specific inhibitory receptors controlling NK cell activity paved the way to the fundamental concept of modulating immune responses that are regulated by an array of inhibitory receptors, and emphasized the importance to explore the potential of NK cells in cancer therapy. Although a whole range of NK cell-based approaches are currently being developed, there are still major challenges that need to be overcome for improved efficacy of these therapies. These include escape of tumor cells from N

SUBMITTER: Seliger B 

PROVIDER: S-EPMC9422402 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature