Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.

ABSTRACT:

Introduction

Chronic rhinosinusitis is a multifactorial disease whose pathogenesis, influenced by both genetic and environmental factors, is still unclear. Previous genetic studies have shown that patients with chronic rhinosinusitis have reduced expression of the Interleukin-22 (IL-22) gene.

Objective

Identify and compare the frequency of polymorphisms in the IL22RA1 gene (IL22 alpha-1 subunit receptor) among chronic rhinosinusitis patients - either with or without nasal polyps.

Methods

Peripheral blood samples were collected from 70 chronic rhinosinusitis with polyps patients, 14 chronic rhinosinusitis without polyps patients and 68 subjects without chronic rhinosinusitis, followed by DNA extraction and IL22RA1 gene sequence analysis.

Results

Among ten polymo

SUBMITTER: Dinarte VRP 

PROVIDER: S-EPMC9422405 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature