IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate.

ABSTRACT:

Introduction

Non-syndromic orofacial clefts have a complex etiology due to the contribution from both genetic and environmental risk factors, as well as the interaction between them. Among the more than 15 susceptibility loci for non-syndromic orofacial clefts with considerable statistical and biological support, the IRF6 is the most validated gene by the majority of studies. Nonetheless, in genetically heterogeneous populations such as Brazilian, the confirmation of association between non-syndromic orofacial clefts and IRF6 common variants is not a consolidated fact and unrecognized IRF6 variants are poorly investigated.

Objective

The aim of this study was to investigate the association of IRF6 polymorphisms with non-syndromic orofacial clefts development in a population f

SUBMITTER: Bezerra JF 

PROVIDER: S-EPMC9422540 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature