Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae.

ABSTRACT: The costs of coronavirus disease 2019 (COVID-19) are devastating. With millions of deaths worldwide, specific serological biomarkers, antiviral agents, and novel therapies are urgently required to reduce the disease burden. For these purposes, a profound understanding of the pathobiology of COVID-19 is mandatory. Notably, the study of immunity against other respiratory infections has generated reference knowledge to comprehend the paradox of the COVID-19 pathogenesis. Past studies point to a complex interplay between cytokines and other factors mediating wound healing and extracellular matrix (ECM) remodeling that results in exacerbated inflammation, tissue injury, severe manifestations, and a sequela of respiratory infections. This review provides an overview of the immunological process

SUBMITTER: Ramirez-Martinez G 

PROVIDER: S-EPMC9422783 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature