General practice database on mortality in adults on methylphenidate: cohort study.

ABSTRACT:

Objectives

Methylphenidate is a 'prescription only' drug against attention disorders which is increasingly used by adults. We investigated whether methylphenidate in adults was associated with an increased risk of psychiatric events such as depression, and suicide attempt and overall mortality.

Design

A population-based matched cohort design.

Setting

The Integrated Primary Care Information system, a general practitioners (GP) database in the Netherlands with a source population of 2.5 million inhabitants.

Participants

During the study period between 1 June 1996 and 1 January 2018, 8905 adults started methylphenidate and were matched to 10 non-users on sex, age, GP practice and ad prescription date. The total study population consisted of 97 198 participants.

SUBMITTER: Stricker B 

PROVIDER: S-EPMC9422798 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature