Head injury and 25-year risk of dementia.

ABSTRACT:

Introduction

Head injury is associated with significant morbidity and mortality. Long-term associations of head injury with dementia in community-based populations are less clear.

Methods

Prospective cohort study of 14,376 participants (mean age 54 years at baseline, 56% female, 27% Black, 24% with head injury) enrolled in the Atherosclerosis Risk in Communities (ARIC) Study. Head injury was defined using self-report and International Classification of Diseases, Ninth/Tenth Revision (ICD-9/10) codes. Dementia was defined using cognitive assessments, informant interviews, and ICD-9/10 and death certificate codes.

Results

Head injury was associated with risk of dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.3-1.57), with evidence of dose-response (

SUBMITTER: Schneider ALC 

PROVIDER: S-EPMC9422954 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature