A comparative investigation on H3K27ac enhancer activities in the brain and liver tissues between wild boars and domesticated pigs.

ABSTRACT: Dramatic phenotypic differences between domestic pigs and wild boars (Sus scrofa) provide opportunities to investigate molecular mechanisms underlying the formation of complex traits, including morphology, physiology and behaviour. Most studies comparing domestic pigs and wild boars have focused on variations in DNA sequences and mRNA expression, but not on epigenetic changes. Here, we present a genome-wide comparative study on H3K27ac enhancer activities and the corresponding mRNA profiling in the brain and liver tissues of adult Bama Xiang pigs (BMXs) and Chinese wild boars (CWBs). We identified a total of 1,29,487 potential regulatory elements, among which 11,241 H3K27ac peaks showed differential activity between CWBs and BMXs in at least one tissue. These peaks were overr

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9423090 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature