14-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes.

ABSTRACT:

Background

Pre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, and prevent DM development. In the present study, we hypothesized that physical exercise training could modify the epigenetic patterns of women with poor glycemic control.

Methods

48 post-menopause women aged 60.3 ± 4.5 years were divided according to their fasting blood glucose levels into two groups: Prediabetes Group, PG (n=24), and Normal Glucose Group, NGG (n=24). All partic

SUBMITTER: Yumi Noronha N 

PROVIDER: S-EPMC9423096 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature