Dataset Information

Development and validation of the predictive score for pediatric COVID-19 pneumonia: A nationwide, multicenter study.

ABSTRACT:

Background

Due to the possibility of asymptomatic pneumonia in children with COVID-19 leading to overexposure to radiation and problems in limited-resource settings, we conducted a nationwide, multi-center study to determine the risk factors of pneumonia in children with COVID-19 in order to create a pediatric pneumonia predictive score, with score validation.

Methods

This was a retrospective cohort study done by chart review of all children aged 0-15 years admitted to 13 medical centers across Thailand during the study period. Univariate and multivariate analyses as well as backward and forward stepwise logistic regression were used to generate a final prediction model of the pneumonia score. Data during the pre-Delta era was used to create a prediction model whilst data from the Delta one was used as a validation cohort.

Results

The score development cohort consisted of 1,076 patients in the pre-Delta era, and the validation cohort included 2,856 patients in the Delta one. Four predictors remained after backward and forward stepwise logistic regression: age < 5 years, number of comorbidities, fever, and dyspnea symptoms. The predictive ability of the novel pneumonia score was acceptable with the area under the receiver operating characteristics curve of 0.677 and a well-calibrated goodness-of-fit test (p = 0.098). The positive likelihood ratio for pneumonia was 0.544 (95% confidence interval (CI): 0.491-0.602) in the low-risk category, 1.563 (95% CI: 1.454-1.679) in the moderate, and 4.339 (95% CI: 2.527-7.449) in the high-risk.

Conclusion

This study created an acceptable clinical prediction model which can aid clinicians in performing an appropriate triage for children with COVID-19.

SUBMITTER: Satdhabudha A

PROVIDER: S-EPMC9423652 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Development and validation of the predictive score for pediatric COVID-19 pneumonia: A nationwide, multicenter study.

Satdhabudha Araya A Chaiyakulsil Chanapai C Uppala Rattapon R Niyomkarn Watit W Tovichien Prakarn P Norasettekul Vasinee V Ruangnapa Kanokpan K Smathakanee Chutima C Choursamran Bararee B Kulbun Aunya A Jaroenying Rasintra R Kamalaporn Harutai H Sriboonyong Tidarat T Roekworachai Koonkoaw K Sunkonkit Kanokkarn K Tangsathapornpong Auchara A Bunjoungmanee Pornumpa P Pao-In Wanida W Thaweekul Patcharapa P Tantiyavarong Pichaya P Ratanavongkosol Thanyarat T Thongnual Chutima C Sritipsukho Paskorn P Deerojanawong Jitladda J

PloS one 20220829 8

<h4>Background</h4>Due to the possibility of asymptomatic pneumonia in children with COVID-19 leading to overexposure to radiation and problems in limited-resource settings, we conducted a nationwide, multi-center study to determine the risk factors of pneumonia in children with COVID-19 in order to create a pediatric pneumonia predictive score, with score validation.<h4>Methods</h4>This was a retrospective cohort study done by chart review of all children aged 0-15 years admitted to 13 medical ...[more]

PMID: 36037228

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Dataset Information

Development and validation of the predictive score for pediatric COVID-19 pneumonia: A nationwide, multicenter study.

Background

Methods

Results

Conclusion

Publications

Development and validation of the predictive score for pediatric COVID-19 pneumonia: A nationwide, multicenter study.

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