Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens.

ABSTRACT: Epigenetic modifications can contribute to adaptation, but the relative contributions of genetic and epigenetic variation are unknown. Previous studies on the role of epigenetic changes in adaptation in eukaryotes have nearly exclusively focused on cytosine methylation (m5C), while prokaryotes exhibit a richer system of methyltransferases targetting adenines (m6A) or cytosines (m4C, m5C). DNA methylation in prokaryotes has many roles, but its potential role in adaptation still needs further investigation. We collected phenotypic, genetic, and epigenetic data using single molecule real-time sequencing of clones of the bacterium Serratia marcescens that had undergone experimental evolution in contrasting temperatures to investigate the relationship between environment and genetic, epi

SUBMITTER: Bruneaux M 

PROVIDER: S-EPMC9423861 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature