M⁶A Regulator-Based Exosomal Gene Methylation Modification Patterns Identify Distinct Microenvironment Characterization and Predict Immunotherapeutic Responses in Colon Cancer.

ABSTRACT: Recent studies have highlighted the biological significance of exosomes and m⁶A modifications in immunity. Nonetheless, it remains unclear whether the m⁶A modification gene in exosomes of body fluid has potential roles in the tumor microenvironment (TME). Herein, we identified three different m⁶A-related exosomal gene modification patterns based on 59 m⁶A-related exosomal genes, which instructed distinguishing characteristics of TME in colon cancer (CC). We demonstrated that these patterns could predict the stage of tumor inflammation, subtypes, genetic variation, and patient prognosis. Furthermore, we developed a scoring mode-m⁶A-related exosomal gene score (MREGS)-by detecting the level of m⁶A modification in exosomes to c

SUBMITTER: Zheng J 

PROVIDER: S-EPMC9423980 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature