Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer.

ABSTRACT: Regulatory T cells (Tregs) are a heterogeneous cell population that can either suppress or stimulate immune responses. Tumor-infiltrating Tregs are associated with an adverse outcome from most cancer types, but have generally been found to be associated with a good prognosis in colorectal cancer (CRC). We investigated the prognostic heterogeneity of Tregs in CRC by co-expression patterns and spatial analyses with diverse T cell markers, using multiplex fluorescence immunohistochemistry and digital image analysis in two consecutive series of primary CRCs (total n = 1720). Treg infiltration in tumors, scored as FOXP3⁺ or CD4⁺/CD25⁺/FOXP3⁺ (triple-positive) cells, was strongly correlated to the overall amount of CD3⁺ and CD8⁺ T

SUBMITTER: Bergsland CH 

PROVIDER: S-EPMC9424114 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature