Outcomes of left atrial appendage occlusion vs. non-vitamin K antagonist oral anticoagulants in atrial fibrillation.

ABSTRACT:

Background

The effects of left atrial appendage (LAA) occlusion compared to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in patients with atrial fibrillation (AF) remain unknown.

Aims

We aimed to evaluate the outcomes in patients with AF who received LAA occlusion vs. NOAC therapy.

Methods

We utilised data from TriNetX which is a global federated health research network currently containing data for 88.5 million patients. ICD-10 codes were employed to identify AF patients treated with either LAA occlusion or NOAC between 1st December 2010 and 17th January 2019. Clinical outcomes of interest were analysed up to 2 years.

Results

108,697 patients were included. Patients who underwent LAA occlusion were younger, more likely to be white Caucasian and m

SUBMITTER: Ding WY 

PROVIDER: S-EPMC9424138 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature