The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma.

ABSTRACT:

Purpose

Uveal melanoma (UM) is the most common intraocular malignancy in adults with a poor prognosis and a high recurrence rate. Currently there is no effective treatment for UM. Multi-kinase inhibitors targeting dysregulated pro-tumorigenic signalling pathways have revolutionised anti-cancer treatment but, as yet, their efficacy in UM has not been established. Here, we identified the multi-kinase inhibitor afatinib as a highly effective agent that exerts anti-UM effects in in vitro, ex vivo and in vivo models.

Methods

We assessed the anti-cancer effects of afatinib using cell viability, cell death and cell cycle assays in in vitro and ex vivo UM models. The signaling pathways involved in the anti-UM effects of afatinib were evaluated by Western blotting. The in vivo activi

SUBMITTER: Shu W 

PROVIDER: S-EPMC9424141 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature