Molecular matched targeted therapies for primary brain tumors-a single center retrospective analysis.

ABSTRACT:

Purpose

Molecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in brain tumor patients. We aimed to evaluate the decision-making process of molecular targeted therapies and analyze data on tolerability as well as signals for efficacy.

Methods

Via retrospective analysis, we identified primary brain tumor patients who were treated off-label with a targeted therapy at the University Hospital Frankfurt, Goethe University. We analyzed which types of molecular alterations were utilized to guide molecular off-label therapies and the diagnostic procedures for their assessment during the period from 2008 to 2021. Data on tolerability and outcomes were collected.

Results

413 off-label therapies wer

SUBMITTER: Luger AL 

PROVIDER: S-EPMC9424147 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature