Genomic copy number alterations as biomarkers for triple negative pregnancy-associated breast cancer.

ABSTRACT:

Background

PABC, commonly defined as breast cancer diagnosed during or ≤ 1 year after pregnancy, accounts for 7% of all breast cancers in women ≤ 45 years. Compared to age-matched non-PABC patients, PABC is characterized by a particularly aggressive histopathologic profile with poorly differentiated and estrogen- and progesterone receptor negative tumors and associated high mortality rates. This study assessed the genomic background of triple-negative PABC tumors by detection of copy number alterations (CNAs).

Methods

MLPA was used to compare CNAs in breast cancer-associated chromosomal loci between triple-negative PABC- and subtype-matched non-PABC patients. Both CNA patterns were evaluated by cluster analysis; associations between individual gene CNAs, pathological charact

SUBMITTER: Suelmann BBM 

PROVIDER: S-EPMC9424154 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature