Cumulative life course adversity, mental health, and cognition in the UK biobank.

ABSTRACT: The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study (N = 73,489, Mdn_age = 56, SD_age = 7.628, 55.740% of women). Cumulative life course adversity (specifically maltreatment) was measured with items based on the Childhood Trauma Questionnair

SUBMITTER: Kunzi M 

PROVIDER: S-EPMC9424182 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature