Genomic discovery and structural dissection of a novel type of polymorphic toxin system in gram-positive bacteria.

ABSTRACT: Bacteria have developed several molecular conflict systems to facilitate kin recognition and non-kin competition to gain advantages in the acquisition of growth niches and of limited resources. One such example is a large class of so-called polymorphic toxin systems (PTSs), which comprise a variety of the toxin proteins secreted via T2SS, T5SS, T6SS, T7SS and many others. These systems are highly divergent in terms of sequence/structure, domain architecture, toxin-immunity association, and organization of the toxin loci, which makes it difficult to identify and characterize novel systems using traditional experimental and bioinformatic strategies. In recent years, we have been developing and utilizing unique genome-mining strategies and pipelines, based on the organizational principles of

SUBMITTER: Li H 

PROVIDER: S-EPMC9424270 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature