Longitudinal corpus callosum microstructural decline in early-stage Parkinson's disease in association with akinetic-rigid symptom severity.

ABSTRACT: Previous diffusion tensor imaging (DTI) studies of Parkinson's disease (PD) show reduced microstructural integrity of the corpus callosum (CC) relative to controls, although the characteristics of such callosal degradation remain poorly understood. Here, we utilized a longitudinal approach to identify microstructural decline in the entire volume of the CC and its functional subdivisions over 2 years and related the callosal changes to motor symptoms in early-stage PD. The study sample included 61 PD subjects (N = 61, aged 45-82, 38 M & 23 F, H&Y ≤ 2) from the Parkinson's Progressive Markers Initiative database (PPMI). Whole-brain voxel-wise results revealed significant fractional anisotropy (FA) and mean diffusivity (MD) changes in the CC, especially in the genu and splenium. Using individ

SUBMITTER: Amandola M 

PROVIDER: S-EPMC9424284 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature