Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany.

ABSTRACT: In the last fifteen years, an epidemic of canine distemper virus (CDV) with marked neurotropism has occurred in Europe after a longer period of endemic transmission. Many wildlife species have been infected, with red foxes (Vulpes vulpes) being particularly affected. Given that this species is assumed to mediate cross-species CDV infections to domestic and wild animals, tissue samples from foxes with confirmed CDV infection in North-Western Germany were investigated to better understand the neurotropic aspects of the disease. This analysis included histopathology, virus distribution and cell tropism, phenotyping of inflammatory responses and determination of the genotype of the viruses based on the phylogeny of the hemagglutinin (H) gene. The predominant lesion type is gliosis in both gray

SUBMITTER: Geiselhardt F 

PROVIDER: S-EPMC9424316 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature