BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact.

ABSTRACT:

Background

Given the plethora of pathophysiologic mechanisms described in idiopathic pulmonary fibrosis (IPF), we hypothesize that the mechanisms driving fibrosis in IPF may be different from one patient to another.

Research question

Do IPF endotypes exist and are they associated with outcome?

Study design and methods

Using a publicly available gene expression dataset retrieved from BAL samples of patients with IPF and control participants (GSE70867), we clustered IPF samples based on a dimension reduction algorithm specifically designed for -omics data, called DDR Tree. After clustering, gene set enrichment analysis was performed for functional annotation, associations with clinical variables and prognosis were investigated, and differences in transcriptional regulat

SUBMITTER: De Sadeleer LJ 

PROVIDER: S-EPMC9424328 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature