Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection.

ABSTRACT:

Background

Up to 80% of patients surviving acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 infection present persistent anomalies in pulmonary function after hospital discharge. There is a limited understanding of the mechanistic pathways linked to post-acute pulmonary sequelae.

Aim

To identify the molecular underpinnings associated with severe lung diffusion involvement in survivors of SARS-CoV-2-induced ARDS.

Methods

Survivors attended to a complete pulmonary evaluation 3 months after hospital discharge. RNA sequencing (RNA-seq) was performed using Illumina technology in whole-blood samples from 50 patients with moderate to severe diffusion impairment (D_LCO<60%) and age- and sex-matched individuals with mild-normal lung function (D

SUBMITTER: Garcia-Hidalgo MC 

PROVIDER: S-EPMC9424524 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature