Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment.

ABSTRACT: Background and Objective: Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups. We focused on the pharmacokinetics of daptomycin in children with renal impairment, which has not been evaluated. Methods: A physiologically based pharmacokinetic (PBPK) model of daptomycin was established and validated to simulate its disposition in healthy populations and adults with renal impairment, along with a daptomycin exposure simulated in pediatric patients with renal impairment. Results: The simulated PBPK modeling results for various regimens of intravenously administered daptomycin were consistent with observed data according to the fold error below the threshold of 2. The C_max and AUC of daptomy

SUBMITTER: Ye L 

PROVIDER: S-EPMC9424659 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature