Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking.

ABSTRACT: Backgroud: Vascular dementia is the second most common cause of dementia after Alzheimer's disease, accounting for an estimated 15% of cases. Recently, Epimedium has attracted great attention for its potential neuroprotective benefit. However, the direct role and mechanism of Epimedium on vascular dementia still lack systematic research. To systematically explore the possible pharmacological mechanism of Epimedium for the treatment of vascular dementia, network pharmacology, molecular docking, combined with experiment validation were conducted. Methods: The bioactive compounds and targets of Epimedium were obtained from the TCMSP database. The potential targets of vascular dementia were identified from the DrugBank, OMIM, Genecards, Therapeutic Target Database, and DisGeNET d

SUBMITTER: Xie C 

PROVIDER: S-EPMC9424771 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature