Biomechanical properties of native and cultured red blood cells-Interplay of shape, structure and biomechanics.

ABSTRACT: Modern medicine increases the demand for safe blood products. Ex vivo cultured red blood cells (cRBC) are eagerly awaited as a standardized, safe source of RBC. Established culture models still lack the terminal cytoskeletal remodeling from reticulocyte to erythrocyte with changes in the biomechanical properties and interacts with membrane stiffness, viscosity of the cytoplasm and the cytoskeletal network. Comprehensive data on the biomechanical properties of cRBC are needed to take the last step towards translation into clinical use in transfusion medicine. Aim of the study was the comparative analysis of topographical and biomechanical properties of cRBC, generated from human CD34⁺ adult hematopoietic stem/progenitor cells, with native reticulocytes (nRET) and erythrocy

SUBMITTER: Bernecker C 

PROVIDER: S-EPMC9424772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature