Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis.

ABSTRACT:

Objective

Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associated to the severity of many human pathologies, including bacterial/fungal sepsis and COVID-19. Prominent and promising laboratory features in classic and viral sepsis emphasize monocyte distribution width (MDW), due to its ability to distinguish and stratify patients at higher risk of critical conditions or death. No data are available on the roles of histones as MDW modifiers.

Design

Comparison of MDW index was undertaken by routine hematology analyzer on whole blood samples from patients with COVID-19 and Sepsis. The impact of histones on the MDW characteris

SUBMITTER: Ligi D 

PROVIDER: S-EPMC9424804 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature