CASC11 and PVT1 spliced transcripts play an oncogenic role in colorectal carcinogenesis.

ABSTRACT: Cancer is fundamentally a genetic disorder that alters cellular information flow toward aberrant growth. The coding part accounts for less than 2% of the human genome, and it has become apparent that aberrations within the noncoding genome drive important cancer phenotypes. The numerous carcinogenesis-related genomic variations in the 8q24 region include single nucleotide variations (SNVs), copy number variations (CNVs), and viral integrations occur in the neighboring areas of the MYC locus. It seems that MYC is not the only target of these alterations. The MYC-proximal mutations may act via regulatory noncoding RNAs (ncRNAs). In this study, gene expression analyses indicated that the expression of some PVT1 spliced linear transcripts, CircPVT1,

SUBMITTER: Zamani M 

PROVIDER: S-EPMC9424822 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature