The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.

ABSTRACT: The extent of grey matter demyelination and neurodegeneration in the progressive multiple sclerosis (PMS) brains at post-mortem associates with more severe disease. Regional tissue atrophy, especially affecting the cortical and deep grey matter, including the thalamus, is prognostic for poor outcomes. Microglial and complement activation are important in the pathogenesis and contribute to damaging processes that underlie tissue atrophy in PMS. We investigated the extent of pathology and innate immune activation in the thalamus in comparison to cortical grey and white matter in blocks from 21 cases of PMS and 10 matched controls. Using a digital pathology workflow, we show that the thalamus is invariably affected by demyelination and had a far higher proportion of active inflammatory lesion

SUBMITTER: Cooze BJ 

PROVIDER: S-EPMC9425007 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature