Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients.

ABSTRACT:

Background

α-1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study, we explored the association of serum FUT8 activity with renal tubulointerstitial injury in IgAN patients.

Methods

Serum FUT8 activity was measured in 135 IgAN patients and 68 healthy controls from January 2016 to December 2018. The relationships of serum FUT8 activity with clinical and pathological features were analyzed.

Results

Relative to healthy controls, IgAN patients had significantly higher serum FUT8 activity and upregulation of renal FUT8 protein (p < .05). Among IgAN patients, there was a positive correlatio

SUBMITTER: Yang N 

PROVIDER: S-EPMC9425009 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature