Implementation of anti-HDV reflex testing among HBsAg-positive individuals increases testing for hepatitis D.

ABSTRACT:

Background & aims

Although EASL guidelines recommend anti-HDV testing in all HBsAg-positive individuals, HDV infection remains an underdiagnosed condition. We describe the impact of an HDV screening program by reflex anti-HDV testing in all HBsAg-positive samples and compare the results before and after its implementation.

Methods

In total, 2,236 HBsAg-positive determinations were included from January 2018 to December 2021. Only the first sample from each participant was evaluated: 1,492 samples before reflex anti-HDV testing (2018-2020) and 744 samples after (2021). Demographic and clinical characteristics of anti-HDV-positive patients were collected.

Results

Before reflex testing, anti-HDV had been tested in 7.6% (114/1492) of HBsAg-positive individuals: 23% (91/39

SUBMITTER: Palom A 

PROVIDER: S-EPMC9425021 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature