Dataset Information

Oral antibiotics perturbation on gut microbiota after prostate biopsy.

ABSTRACT:

Introduction

The use of antibiotics may induce the changes in gut microbiota. Previous studies have shown conflicting results on whether the changed gut microbiota by antibiotics can be recovered. Our study aims to investigate whether the gut microbiota could be recovered after a single dose of oral co-amoxiclav before transrectal ultrasound-guided transperineal prostate biopsy (TPPBx) in 5 weeks' time.

Methods

Fifteen patients with elevated serum prostate-specific antigen (PSA) were recruited to provide pre-antibiotic and post-antibiotic fecal samples. The V4 region of 16S rRNA was sequenced. Analysis was performed by QIIME2. Alpha- and beta-diversities were analyzed, as well as the differential enrichment by Linear discriminant analysis Effect Size (LEfSe) analysis.

Results

Both the alpha- and beta-diversities of the pre- and post-antibiotic fecal samples were significantly different. Genera that are associated with alleviation of inflammation were enriched in the pre-antibiotic fecal samples, while the inflammation-associated genera were more enriched in the post-antibiotic fecal samples.

Conclusion

A single dose of oral co-amoxiclav before TPPBx could have led to a change of gut microbiota that cannot be recovered in 5 weeks' time. Microbiome studies on prostate cancer patients should be cautioned on the use of post-prostate biopsy fecal sampling. Further studies should be conducted for the impact on gut microbiome for TPPBx alone.

SUBMITTER: Li JKM

PROVIDER: S-EPMC9425026 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Oral antibiotics perturbation on gut microbiota after prostate biopsy.

Li Joseph Kai Man JKM Wang Lynn Lin LL Lau Becky Su Yan BSY Tse Ryan Tsz Hei RTH Cheng Carol Ka Lo CKL Leung Steven Chi Ho SCH Wong Christine Yim Ping CYP Tsui Stephen Kwok Wing SKW Teoh Jeremy Yuen Chun JYC Chiu Peter Ka Fung PKF Ng Chi Fai CF

Frontiers in cellular and infection microbiology 20220816

<h4>Introduction</h4>The use of antibiotics may induce the changes in gut microbiota. Previous studies have shown conflicting results on whether the changed gut microbiota by antibiotics can be recovered. Our study aims to investigate whether the gut microbiota could be recovered after a single dose of oral co-amoxiclav before transrectal ultrasound-guided transperineal prostate biopsy (TPPBx) in 5 weeks' time.<h4>Methods</h4>Fifteen patients with elevated serum prostate-specific antigen (PSA) w ...[more]

PMID: 36051239

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Dataset Information

Oral antibiotics perturbation on gut microbiota after prostate biopsy.

Introduction

Methods

Results

Conclusion

Publications

Oral antibiotics perturbation on gut microbiota after prostate biopsy.

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