Secretagogin is a Ca²⁺-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies.

ABSTRACT: Secretagogin (SCGN) is a three-domain hexa-EF-hand Ca²⁺-binding protein that plays a regulatory role in the release of several hormones. SCGN is expressed largely in pancreatic β-cells, certain parts of the brain, and also in neuroendocrine tissues. The expression of SCGN is altered in several diseases, such as diabetes, cancers, and neurodegenerative disorders; however, the precise associations that closely link SCGN expression to such pathophysiologies are not known. In this work, we report that SCGN is an early responder to cellular stress, and SCGN expression is temporally upregulated by oxidative stress and heat shock. We show the overexpression of SCGN efficiently prevents cells from heat shock and oxidative damage. We further demonstrate that in the presence of Ca^2+<

SUBMITTER: Chidananda AH 

PROVIDER: S-EPMC9425029 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature