Ubiquitination as a key regulatory mechanism for O₃-induced cutaneous redox inflammasome activation.

ABSTRACT: NLRP1 is one of the major inflammasomes modulating the cutaneous inflammatory responses and therefore linked to a variety of cutaneous conditions. Although NLRP1 has been the first inflammasome to be discovered, only in the past years a significant progress was achieved in understanding the molecular mechanism and the stimuli behind its activation. In the past decades a crescent number of studies have highlighted the role of air pollutants as Particulate Matter (PM), Cigarette Smoke (CS) and Ozone (O₃) as trigger stimuli for inflammasomes activation, especially via Reactive Oxygen Species (ROS) mediators. However, whether NLRP1 can be modulated by air pollutants via oxidative stress and the mechanism behind its activation is still poorly understood. Here we report for the first

SUBMITTER: Ferrara F 

PROVIDER: S-EPMC9425076 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature