The role of ERBB2 gene polymorphisms in leprosy susceptibility.
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ABSTRACT:
SUBMITTER: Rego JL
PROVIDER: S-EPMC9425388 | biostudies-literature | 2015 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
The role of ERBB2 gene polymorphisms in leprosy susceptibility.
Rêgo Jamile Leão JL Oliveira Joyce Moura JM Santana Nadja de Lima Nde L Machado Paulo Roberto Lima PR Castellucci Léa Cristina LC
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20150127 2
Mycobacterium leprae infects skin and peripheral nerves causing deformities and disability. The M. leprae bacterium binds to ErbB2 on the Schwann cell surface causing demyelination and favoring spread of the bacilli and causing nerve injury. Polymorphisms at the ERBB2 gene were previously investigated as genetic risk factors for leprosy in two Brazilian populations but with inconsistent results. Herein we extend the analysis of ERBB2 variants to a third geographically distinct population in Braz ...[more]
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