Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma).

ABSTRACT: The kernels of the Australian blushwood tree (Fontainea picrosperma) are the source of the veterinary anticancer drug tigilanol tiglate (2a, Stelfonta) and contain a concentration of phorboids significantly higher than croton oil, the only abundant source of these compounds previously known. The oily matrix of the blushwood kernels is composed of free fatty acids and not by glycerides as found in croton oil. By active partitioning, it was therefore possible to recover and characterize for the first time a cryptic tigliane fraction, that is, the diterpenoid fraction that, because of its lipophilicity, could not be obtained by solvent partition of crude extracts. The cryptic tigliane fraction accounted for ca. 30% of the tigliane kernel titer and was quantified by ¹H

SUBMITTER: Chianese G 

PROVIDER: S-EPMC9425429 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature